Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types

Autoantibodies to citrullinated proteins (ACPAs) are present in two-thirds of patients with rheumatoid arthritis (RA). ACPAs are produced in the absence of identified T cell responses for each citrullinated protein. Peptidyl arginine deiminase 4 (PAD4), which binds proteins and citrullinates them, i...

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Detalles Bibliográficos
Autores principales: Arnoux, Fanny, Mariot, Charlotte, Peen, Elisa, Lambert, Nathalie C., Balandraud, Nathalie, Roudier, Jean, Auger, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703315/
https://www.ncbi.nlm.nih.gov/pubmed/29109281
http://dx.doi.org/10.1073/pnas.1713112114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703315/
https://www.ncbi.nlm.nih.gov/pubmed/29109281
http://dx.doi.org/10.1073/pnas.1713112114

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