Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts

Wnt3a is a major regulator of bone metabolism however, very few of its target genes are known in bone. Wnt3a preferentially signals through transmembrane receptors Frizzled and co-receptors Lrp5/6 to activate the canonical signaling pathway. Previous studies have shown that the canonical Wnt co-rece...

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Detalles Bibliográficos
Autores principales: Sebastian, Aimy, Hum, Nicholas R., Murugesh, Deepa K., Hatsell, Sarah, Economides, Aris N., Loots, Gabriela G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703471/
https://www.ncbi.nlm.nih.gov/pubmed/29176883
http://dx.doi.org/10.1371/journal.pone.0188264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703471/
https://www.ncbi.nlm.nih.gov/pubmed/29176883
http://dx.doi.org/10.1371/journal.pone.0188264

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