Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus

The evolutional process of disease-associated autoantibodies in systemic lupus erythematosus (SLE) remains to be established. Here we show intraclonal diversification and affinity maturation of anti-nuclear antibody (ANA)-producing B cells in SLE. We identified a panel of monoclonal ANAs recognizing...

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Detalles Bibliográficos
Autores principales: Sakakibara, Shuhei, Arimori, Takao, Yamashita, Kazuo, Jinzai, Hideyuki, Motooka, Daisuke, Nakamura, Shota, Li, Songling, Takeda, Kazuya, Katayama, Jun, El Hussien, Marwa Ali, Narazaki, Masashi, Tanaka, Toshio, Standley, Daron M., Takagi, Junichi, Kikutani, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703881/
https://www.ncbi.nlm.nih.gov/pubmed/29180749
http://dx.doi.org/10.1038/s41598-017-16681-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703881/
https://www.ncbi.nlm.nih.gov/pubmed/29180749
http://dx.doi.org/10.1038/s41598-017-16681-y

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