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ATF4 overexpression induces early onset of hyperlipidaemia and hepatic steatosis and enhances adipogenesis in zebrafish

Activating transcription factor 4 (ATF4) is constitutively expressed in a variety of tissues, and regulates several pathological features associated with metabolic diseases such as non-alcoholic fatty liver diseases (NAFLD) and obesity. However, the role of ATF4 in animal model systems is poorly und...

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Detalles Bibliográficos
Autores principales: Yeh, Kun-Yun, Lai, Chi-Yu, Lin, Chiu-Ya, Hsu, Chia-Chun, Lo, Chung-Ping, Her, Guor Mour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703967/
https://www.ncbi.nlm.nih.gov/pubmed/29180630
http://dx.doi.org/10.1038/s41598-017-16587-9