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Features of reactive cysteines discovered through computation: from kinase inhibition to enrichment around protein degrons
Large-scale characterisation of cysteine modification is enabling study of the physicochemical determinants of reactivity. We find that location of cysteine at the amino terminus of an α-helix, associated with activity in thioredoxins, is under-represented in human protein structures, perhaps indica...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703995/ https://www.ncbi.nlm.nih.gov/pubmed/29180682 http://dx.doi.org/10.1038/s41598-017-15997-z |