Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type-I(1/2) Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation

[Image: see text] Targeted inhibition of anaplastic lymphoma kinase (ALK) dramatically improved therapeutic outcomes in the treatment of ALK-positive cancers, but unfortunately patients invariably progressed due to acquired resistance mutations in ALK. Currently available drugs are all type-I inhibi...

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Detalles Bibliográficos
Autores principales: Pan, Peichen, Yu, Huidong, Liu, Qinglan, Kong, Xiaotian, Chen, Hu, Chen, Jiean, Liu, Qi, Li, Dan, Kang, Yu, Sun, Huiyong, Zhou, Wenfang, Tian, Sheng, Cui, Sunliang, Zhu, Feng, Li, Youyong, Huang, Yong, Hou, Tingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704298/
https://www.ncbi.nlm.nih.gov/pubmed/29202023
http://dx.doi.org/10.1021/acscentsci.7b00419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704298/
https://www.ncbi.nlm.nih.gov/pubmed/29202023
http://dx.doi.org/10.1021/acscentsci.7b00419

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