Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells

BACKGROUND: As the important suppressor of P53, iASPP is found to be overexpressed in leukemia, and functions as oncogene that inhibited apoptosis of leukemia cells. Sertad1 is identified as one of the proteins that can bind with iASPP in our previous study by two-hybrid screen. METHODS: Co-immunopr...

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Detalles Bibliográficos
Autores principales: Qiu, Shaowei, Liu, Shuang, Yu, Tengteng, Yu, Jing, Wang, Min, Rao, Qing, Xing, Haiyan, Tang, Kejing, Mi, Yinchang, Wang, Jianxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704379/
https://www.ncbi.nlm.nih.gov/pubmed/29179704
http://dx.doi.org/10.1186/s12885-017-3787-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704379/
https://www.ncbi.nlm.nih.gov/pubmed/29179704
http://dx.doi.org/10.1186/s12885-017-3787-2

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