Cargando…
Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells
BACKGROUND: As the important suppressor of P53, iASPP is found to be overexpressed in leukemia, and functions as oncogene that inhibited apoptosis of leukemia cells. Sertad1 is identified as one of the proteins that can bind with iASPP in our previous study by two-hybrid screen. METHODS: Co-immunopr...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704379/ https://www.ncbi.nlm.nih.gov/pubmed/29179704 http://dx.doi.org/10.1186/s12885-017-3787-2 |