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Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production

The expression of normal cellular prion protein (PrP) is required for the pathogenesis of prion diseases. However, the physiological functions of PrP remain ambiguous. Here, we identified PrP as being critical for tumor necrosis factor (TNF) α-triggered signaling in a human melanoma cell line, M2, a...

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Detalles Bibliográficos
Autores principales: Wu, Gui-Ru, Mu, Tian-Chen, Gao, Zhen-Xing, Wang, Jun, Sy, Man-Sun, Li, Chao-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704461/
https://www.ncbi.nlm.nih.gov/pubmed/28900035
http://dx.doi.org/10.1074/jbc.M117.787283