Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations

BACKGROUND: Previous studies have indicated that tumor mitochondrial DNA (mtDNA) mutations are primarily shaped by relaxed negative selection, which is contradictory to the critical roles of mtDNA mutations in tumorigenesis. Therefore, we hypothesized that site-specific selection may influence tumor...

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Detalles Bibliográficos
Autores principales: Li, Deyang, Du, Xiaohong, Guo, Xu, Zhan, Lei, Li, Xin, Yin, Chun, Chen, Cheng, Li, Mingkun, Li, Bingshan, Yang, Hushan, Xing, Jinliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704541/
https://www.ncbi.nlm.nih.gov/pubmed/29179728
http://dx.doi.org/10.1186/s13046-017-0638-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704541/
https://www.ncbi.nlm.nih.gov/pubmed/29179728
http://dx.doi.org/10.1186/s13046-017-0638-6

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