Identification of biomarkers of response to abatacept in patients with SLE using deconvolution of whole blood transcriptomic data from a phase IIb clinical trial

OBJECTIVE: To characterise patients with active SLE based on pretreatment gene expression-defined peripheral immune cell patterns and identify clusters enriched for potential responders to abatacept treatment. METHODS: This post hoc analysis used baseline peripheral whole blood transcriptomic data f...

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Detalles Bibliográficos
Autores principales: Bandyopadhyay, Somnath, Connolly, Sean E, Jabado, Omar, Ye, June, Kelly, Sheila, Maldonado, Michael A, Westhovens, Rene, Nash, Peter, Merrill, Joan T, Townsend, Robert M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Biomarker Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704740/
https://www.ncbi.nlm.nih.gov/pubmed/29214034
http://dx.doi.org/10.1136/lupus-2017-000206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704740/
https://www.ncbi.nlm.nih.gov/pubmed/29214034
http://dx.doi.org/10.1136/lupus-2017-000206

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