Cargando…

Identification of biomarkers of response to abatacept in patients with SLE using deconvolution of whole blood transcriptomic data from a phase IIb clinical trial

OBJECTIVE: To characterise patients with active SLE based on pretreatment gene expression-defined peripheral immune cell patterns and identify clusters enriched for potential responders to abatacept treatment. METHODS: This post hoc analysis used baseline peripheral whole blood transcriptomic data f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bandyopadhyay, Somnath, Connolly, Sean E, Jabado, Omar, Ye, June, Kelly, Sheila, Maldonado, Michael A, Westhovens, Rene, Nash, Peter, Merrill, Joan T, Townsend, Robert M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Biomarker Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704740/ https://www.ncbi.nlm.nih.gov/pubmed/29214034 http://dx.doi.org/10.1136/lupus-2017-000206

Ejemplares similares

Erythrocyte-bound C4d in combination with complement and autoantibody status for the monitoring of SLE
por: Merrill, Joan T, et al.
Publicado: (2018)

Loss of antiphospholipid antibody positivity post-thrombosis in SLE
por: Khawaja, Muznay, et al.
Publicado: (2020)

Association of the interferon signature metric with serological disease manifestations but not global activity scores in multiple cohorts of patients with SLE
por: Kennedy, William P, et al.
Publicado: (2015)

Novel immunoprofiling method for diagnosing SLE and evaluating therapeutic response
por: Lee, Jan-Mou, et al.
Publicado: (2022)

Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE
por: Yuan, Shiwen, et al.
Publicado: (2022)

Osteopontin is associated with disease severity and antiphospholipid syndrome in well characterised Swedish cases of SLE
por: Wirestam, Lina, et al.
Publicado: (2017)

Comparison of PREDICTS atherosclerosis biomarker changes after initiation of new treatments in patients with SLE
por: McMahon, Maureen, et al.
Publicado: (2019)

Type I interferon receptor blockade with anifrolumab corrects innate and adaptive immune perturbations of SLE
por: Casey, Kerry A, et al.
Publicado: (2018)

Platelet-bound C4d, low C3 and lupus anticoagulant associate with thrombosis in SLE
por: Petri, Michelle A, et al.
Publicado: (2019)

Assessment of the independent associations of IgG, IgM and IgA isotypes of anticardiolipin with thrombosis in SLE
por: Domingues, Vinicius, et al.
Publicado: (2016)

Randomised prospective trial to assess the clinical utility of multianalyte assay panel with complement activation products for the diagnosis of SLE
por: Wallace, Daniel J, et al.
Publicado: (2019)

DNA topoisomerase VIII: a novel subfamily of type IIB topoisomerases encoded by free or integrated plasmids in Archaea and Bacteria
por: Gadelle, Danièle, et al.
Publicado: (2014)

Different indirect immunofluorescence ANA substrate performance in a diagnostic setting of patients with SLE and related disorders: retrospective review and analysis
por: Choi, May Y, et al.
Publicado: (2020)

Associations between circulating interferon and kynurenine/tryptophan pathway metabolites: support for a novel potential mechanism for cognitive dysfunction in SLE
por: Anderson, Erik W, et al.
Publicado: (2022)

Deconvolution of malignant pleural effusions immune landscape unravels a novel macrophage signature associated with worse clinical outcome in lung adenocarcinoma patients
por: Bruschini, Sara, et al.
Publicado: (2022)

Effect of anti-P ribosomal and anti-NR2 antibodies on depression and cognitive processes in SLE: an integrated clinical and functional MRI study
por: Chessa, Elisabetta, et al.
Publicado: (2023)

Anxiety and depression severity in neuropsychiatric SLE are associated with perfusion and functional connectivity changes of the frontolimbic neural circuit: a resting-state f(unctional) MRI study
por: Antypa, Despina, et al.
Publicado: (2021)

Clinical implications of discordance between anti-dsDNA antibodies by multiplex flow immunoassay and Crithidia luciliae assay in a multiethnic racial cohort of patients with SLE
por: Zaminski, Devyn, et al.
Publicado: (2023)

BAFF (B cell activating factor) transcript level in peripheral blood of patients with SLE is associated with same-day disease activity as well as global activity over the next year
por: Zollars, Eric, et al.
Publicado: (2015)

Erythrocyte complement receptor 1 (ECR1) and erythrocyte-bound C4d (EC4d) in the prediction of poor pregnancy outcomes in systemic lupus erythematosus (SLE)
por: Conklin, John, et al.
Publicado: (2022)

Autoantibodies associated with systemic sclerosis in three autoimmune diseases imprinted by type I interferon gene dysregulation: a comparison across SLE, primary Sjögren’s syndrome and systemic sclerosis
por: Andraos, Rama, et al.
Publicado: (2022)

Differential Changes in ACPA Fine Specificity and Gene Expression in a Randomized Trial of Abatacept and Adalimumab in Rheumatoid Arthritis
por: Jabado, Omar, et al.
Publicado: (2021)

Conversion to seronegative status after abatacept treatment in patients with early and poor prognostic rheumatoid arthritis is associated with better radiographic outcomes and sustained remission: post hoc analysis of the AGREE study
por: Jansen, Diahann T S L, et al.
Publicado: (2018)

Implementation of the OMERACT Psoriatic Arthritis Magnetic Resonance Imaging Scoring System in a randomized phase IIb study of abatacept in psoriatic arthritis
por: Østergaard, Mikkel, et al.
Publicado: (2022)

Homoarginine, heart failure, and sudden cardiac death in haemodialysis patients
por: Drechsler, Christiane, et al.
Publicado: (2011)

Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: The NGAL EvaLuation Along with B-type NaTriuretic Peptide in acutely decompensated heart failure (GALLANT) trial
por: Maisel, Alan S., et al.
Publicado: (2011)

Plasma tissue inhibitor of matrix metalloproteinase-1 (TIMP-1): an independent predictor of poor response to cardiac resynchronization therapy
por: Tolosana, Jose María, et al.
Publicado: (2010)

The novel biomarker growth differentiation factor 15 in heart failure with normal ejection fraction
por: Stahrenberg, Raoul, et al.
Publicado: (2010)

Circulating microRNAs for predicting and monitoring response to mechanical circulatory support from a left ventricular assist device
por: Morley-Smith, Andrew C, et al.
Publicado: (2014)

Test-Retest Reliability of Diffusion Tensor Imaging in Huntington’s Disease
por: Cole, James H., et al.
Publicado: (2014)

Carbamylated vimentin represents a relevant autoantigen in Latin American (Cuban) rheumatoid arthritis patients
por: Martínez, Goitybell, et al.
Publicado: (2016)

Quantification of the Light Subunit of Neurofilament Protein in Cerebrospinal Fluid of Huntington’s Disease Patients
por: Szejko, Natalia, et al.
Publicado: (2018)

Natriuretic Peptides in Chronic Heart Failure
por: Brunner-La Rocca, Hans-Peter, et al.
Publicado: (2019)

Biomarkers in Routine Heart Failure Clinical Care
por: Nadar, Sunil K, et al.
Publicado: (2019)

Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED‐HF study
por: Welsh, Paul, et al.
Publicado: (2017)

Relationship between outdoor temperature and cardiovascular disease risk factors in older people
por: Sartini, Claudio, et al.
Publicado: (2016)

Variability of biomarkers in patients with chronic heart failure and healthy controls
por: Meijers, Wouter C., et al.
Publicado: (2016)

Urinary peptide-based classifier CKD273: towards clinical application in chronic kidney disease
por: Pontillo, Claudia, et al.
Publicado: (2017)

Clinical proteomics in kidney disease as an exponential technology: heading towards the disruptive phase
por: Sanchez-Niño, Maria Dolores, et al.
Publicado: (2017)

The clinical utility of kinetic glomerular filtration rate
por: O'Sullivan, Eoin D., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ekd6ojligueufr8p3a7ntjqlb1