Effects of peroxisome proliferator activated receptors (PPAR)-γ and -α agonists on cochlear protection from oxidative stress

Various insults cause ototoxicity in mammals by increasing oxidative stress leading to apoptosis of auditory hair cells (HCs). The thiazolidinediones (TZDs; e.g., pioglitazone) and fibrate (e.g., fenofibrate) drugs are used for the treatment of diabetes and dyslipidemia. These agents target the pero...

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Detalles Bibliográficos
Autores principales: Sekulic-Jablanovic, Marijana, Petkovic, Vesna, Wright, Matthew B., Kucharava, Krystsina, Huerzeler, Nathan, Levano, Soledad, Brand, Yves, Leitmeyer, Katharina, Glutz, Andrea, Bausch, Alexander, Bodmer, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705132/
https://www.ncbi.nlm.nih.gov/pubmed/29182629
http://dx.doi.org/10.1371/journal.pone.0188596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705132/
https://www.ncbi.nlm.nih.gov/pubmed/29182629
http://dx.doi.org/10.1371/journal.pone.0188596

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