Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives

The rise in antibiotic resistance is a major threat for human health. Basidiomycete fungi represent an untapped source of underexploited antimicrobials, with pleuromutilin—a diterpene produced by Clitopilus passeckerianus—being the only antibiotic from these fungi leading to commercial derivatives....

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Detalles Bibliográficos
Autores principales: Alberti, Fabrizio, Khairudin, Khairunisa, Venegas, Edith Rodriguez, Davies, Jonathan A., Hayes, Patrick M., Willis, Christine L., Bailey, Andy M., Foster, Gary D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705593/
https://www.ncbi.nlm.nih.gov/pubmed/29184068
http://dx.doi.org/10.1038/s41467-017-01659-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705593/
https://www.ncbi.nlm.nih.gov/pubmed/29184068
http://dx.doi.org/10.1038/s41467-017-01659-1

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