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Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells

Normal epithelial cells are stably connected to each other via the apical junctional complex (AJC). AJCs, however, tend to be disrupted during tumor progression, and this process is implicated in cancer dissemination. Here, using colon carcinoma cells that fail to form AJCs, we investigated molecula...

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Detalles Bibliográficos
Autores principales: Ito, Shoko, Okuda, Satoru, Abe, Masako, Fujimoto, Mari, Onuki, Tetsuo, Nishimura, Tamako, Takeichi, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705652/
https://www.ncbi.nlm.nih.gov/pubmed/29184140
http://dx.doi.org/10.1038/s41467-017-01945-y