Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice

Approximately 90% of alpha-synuclein (α-Synuclein) deposited in Lewy bodies is phosphorylated at serine 129 suggesting that the accumulation of phosphorylated α-Synuclein is critical in the pathogenesis of Parkinson’s disease. However, in vivo experiments addressing the role of phosphorylated α-Synu...

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Detalles Bibliográficos
Autores principales: Karampetsou, Mantia, Ardah, Mustafa T., Semitekolou, Maria, Polissidis, Alexia, Samiotaki, Martina, Kalomoiri, Maria, Majbour, Nour, Xanthou, Georgina, El-Agnaf, Omar M. A., Vekrellis, Kostas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705684/
https://www.ncbi.nlm.nih.gov/pubmed/29184069
http://dx.doi.org/10.1038/s41598-017-15813-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705684/
https://www.ncbi.nlm.nih.gov/pubmed/29184069
http://dx.doi.org/10.1038/s41598-017-15813-8

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