AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts

Inositol Requiring Enzyme-1 (IRE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanism that ensures homeostasis of the endoplasmic reticulum (ER) in eukaryotes. IRE1 activation orchestrates adaptive responses, including lipid anabolism, metabolic reprogr...

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Detalles Bibliográficos
Autores principales: Sanchez-Alvarez, Miguel, del Pozo, Miguel Angel, Bakal, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705697/
https://www.ncbi.nlm.nih.gov/pubmed/29184100
http://dx.doi.org/10.1038/s41598-017-16662-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705697/
https://www.ncbi.nlm.nih.gov/pubmed/29184100
http://dx.doi.org/10.1038/s41598-017-16662-1

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