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Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface

Antibiotic efflux is one of the most critical mechanisms leading to bacterial multidrug resistance. Antibiotics are effluxed out of the bacterial cell by a tripartite efflux pump, a complex machinery comprised of outer membrane, periplasmic adaptor, and inner membrane protein components. Understandi...

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Detalles Bibliográficos
Autores principales: López, Cesar A., Travers, Timothy, Pos, Klaas M., Zgurskaya, Helen I., Gnanakaran, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705723/
https://www.ncbi.nlm.nih.gov/pubmed/29184094
http://dx.doi.org/10.1038/s41598-017-16497-w