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A simulation model of neuroprogenitor proliferation dynamics predicts age-related loss of hippocampal neurogenesis but not astrogenesis

Adult hippocampal neuroprogenitors give rise to both neurons and astrocytes. As neuroprogenitors are lost with increased age, neurogenesis concomitantly decreases. However, the dynamics of neuron and astrocyte generation throughout adulthood has not been systematically examined. Here, we analyzed th...

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Detalles Bibliográficos
Autores principales: Beccari, Sol, Valero, Jorge, Maletic-Savatic, Mirjana, Sierra, Amanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705784/
https://www.ncbi.nlm.nih.gov/pubmed/29184142
http://dx.doi.org/10.1038/s41598-017-16466-3