Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration

Recent work suggested that the activity of extracellular signal-regulated kinase 1/2 (ERK1/2) is increased in the retinal pigment epithelium (RPE) of age-related macular degeneration (ARMD) patients and therefore could be an attractive therapeutic target. Notably, ERK1/2 pathway inhibitors are used...

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Detalles Bibliográficos
Autores principales: Pyakurel, Aswin, Balmer, Delphine, Saba-El-Leil, Marc K., Kizilyaprak, Caroline, Daraspe, Jean, Humbel, Bruno M., Voisin, Laure, Le, Yun Z., von Lintig, Johannes, Meloche, Sylvain, Roduit, Raphaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705814/
https://www.ncbi.nlm.nih.gov/pubmed/29038159
http://dx.doi.org/10.1128/MCB.00295-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705814/
https://www.ncbi.nlm.nih.gov/pubmed/29038159
http://dx.doi.org/10.1128/MCB.00295-17

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