B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis

OBJECTIVES: TNFSF4 (encodes OX40L) is a susceptibility locus for systemic lupus erythematosus (SLE). Risk alleles increase TNFSF4 expression in cell lines, but the mechanism linking this effect to disease is unclear, and the OX40L-expressing cell types mediating the risk are not clearly established....

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Detalles Bibliográficos
Autores principales: Cortini, Andrea, Ellinghaus, Ursula, Malik, Talat H, Cunninghame Graham, Deborah S, Botto, Marina, Vyse, Timothy James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705841/
https://www.ncbi.nlm.nih.gov/pubmed/28818832
http://dx.doi.org/10.1136/annrheumdis-2017-211499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705841/
https://www.ncbi.nlm.nih.gov/pubmed/28818832
http://dx.doi.org/10.1136/annrheumdis-2017-211499

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