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Molecular Dynamics Simulation Reveals Specific Interaction Sites between Scorpion Toxins and K(v)1.2 Channel: Implications for Design of Highly Selective Drugs
The K(v)1.2 channel plays an important role in the maintenance of resting membrane potential and the regulation of the cellular excitability of neurons, whose silencing or mutations can elicit neuropathic pain or neurological diseases (e.g., epilepsy and ataxia). Scorpion venom contains a variety of...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705969/ https://www.ncbi.nlm.nih.gov/pubmed/29104247 http://dx.doi.org/10.3390/toxins9110354 |