TGF-β1/Smad3 Signaling Pathway Mediates T-2 Toxin-Induced Decrease of Type II Collagen in Cultured Rat Chondrocytes

T-2 toxin can cause damage to the articular cartilage, but the molecular mechanism remains unclear. By employing the culture of rat chondrocytes, we investigated the effect of the TGF-β1/Smad3 signaling pathway on the damage to chondrocytes induced by T-2 toxin. It was found that T-2 toxin could red...

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Detalles Bibliográficos
Autores principales: Li, Yang, Zou, Ning, Wang, Jing, Wang, Ke-Wei, Li, Fu-Yuan, Chen, Fu-Xun, Sun, Bing-Yu, Sun, Dian-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705974/
https://www.ncbi.nlm.nih.gov/pubmed/29113082
http://dx.doi.org/10.3390/toxins9110359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705974/
https://www.ncbi.nlm.nih.gov/pubmed/29113082
http://dx.doi.org/10.3390/toxins9110359

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