Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates

Increases in expression of ADAM10 and ADAM17 genes and proteins have been evaluated, but not validated as cancer biomarkers. Specific enzyme activities better reflect enzyme cellular functions, and might be better biomarkers than enzyme genes or proteins. However, no high throughput assay is availab...

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Detalles Bibliográficos
Autores principales: Yoneyama, Toshie, Gorry, Michael, Miller, Miles A, Gaither-Davis, Autumn, Lin, Yan, Moss, Marcia L., Griffith, Linda G., Lauffenburger, Douglas A., Stabile, Laura P., Herman, James G., Vujanovic, Nikola L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705993/
https://www.ncbi.nlm.nih.gov/pubmed/29187866
http://dx.doi.org/10.7150/jca.20779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705993/
https://www.ncbi.nlm.nih.gov/pubmed/29187866
http://dx.doi.org/10.7150/jca.20779

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