The PARP-1 inhibitor Olaparib suppresses BRCA1 protein levels, increases apoptosis and causes radiation hypersensitivity in BRCA1(+/-) lymphoblastoid cells

The use of polyADPribose polymerase inhibitors in cancer treatment provides a unique opportunity to target DNA repair processes in cancer cells while leaving normal tissue intact. The PARP-1 enzyme repairs DNA single strand breaks (SSB). Therefore PARP-1 inhibition in BRCA1 negative cancers results...

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Detalles Bibliográficos
Autores principales: Bourton, Emma C., Ahorner, Pia-Amata, Plowman, Piers N., Zahir, Sheba Adam, Al-Ali, Hussein, Parris, Christopher N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706007/
https://www.ncbi.nlm.nih.gov/pubmed/29187880
http://dx.doi.org/10.7150/jca.21338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706007/
https://www.ncbi.nlm.nih.gov/pubmed/29187880
http://dx.doi.org/10.7150/jca.21338

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