Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists

[Image: see text] Position 6 of the morphinan skeleton plays a key role in the μ-opioid receptor (MOR) activity in vitro and in vivo. We describe the consequence of the 6-carbonyl group deletion in N-methylmorphinan-6-ones 1–4 on ligand–MOR interaction, signaling, and antinociception. While 6-desoxo...

Descripción completa

Detalles Bibliográficos
Autores principales: Dumitrascuta, Maria, Ben Haddou, Tanila, Guerrieri, Elena, Noha, Stefan M., Schläfer, Lea, Schmidhammer, Helmut, Spetea, Mariana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706069/
https://www.ncbi.nlm.nih.gov/pubmed/29053268
http://dx.doi.org/10.1021/acs.jmedchem.7b01363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706069/
https://www.ncbi.nlm.nih.gov/pubmed/29053268
http://dx.doi.org/10.1021/acs.jmedchem.7b01363

Ejemplares similares