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Sirt1 interaction with active Smad2 modulates transforming growth factor-β regulated transcription

BACKGROUND: The simplicity of Transforming Growth Factor ß (TGFβ) signaling pathway, linear and non-amplified, hardly sustains its variety of responses. This is often justified by the complex regulation showed by Smad proteins, TGFβ signaling intracellular transducers, object of post-translational m...

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Detalles Bibliográficos
Autores principales: García-Vizcaíno, Eva María, Liarte, Sergio, Alonso-Romero, José Luis, Nicolás, Francisco José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706420/
https://www.ncbi.nlm.nih.gov/pubmed/29187201
http://dx.doi.org/10.1186/s12964-017-0205-y