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MicroRNA‐30a ameliorates hepatic fibrosis by inhibiting Beclin1‐mediated autophagy

We explored the role of microRNA‐30a (miR‐30a) and the mechanism involved in hepatic fibrosis. MiR‐30a overexpression was achieved by miR‐30a mimics transfection in hepatic stellate cells (HSCs) (HSC‐T6, LX‐2), and miR‐30a agomir (ago‐miR‐30a) treatment in mice. MiR‐30a levels were measured using Ta...

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Detalles Bibliográficos
Autores principales: Chen, Jianliang, Yu, Yue, Li, Shu, Liu, Yuting, Zhou, Shu, Cao, Shouji, Yin, Jie, Li, Guoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706581/
https://www.ncbi.nlm.nih.gov/pubmed/28766848
http://dx.doi.org/10.1111/jcmm.13278