Fingolimod suppresses neuronal autophagy through the mTOR/p70S6K pathway and alleviates ischemic brain damage in mice

The bioactive, signaling lipid, sphingosine-1-phosphate (S1P), and its analog, fingolimod (FTY720), have previously shown neuroprotective effects against ischemic brain injury. However, the underlying mechanisms have not yet been fully clarified. The roles of autophagy in ischemic stroke are being i...

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Detalles Bibliográficos
Autores principales: Li, Xiao, Wang, Ming-Huan, Qin, Chuan, Fan, Wen-Hui, Tian, Dai-Shi, Liu, Jun-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706683/
https://www.ncbi.nlm.nih.gov/pubmed/29186197
http://dx.doi.org/10.1371/journal.pone.0188748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706683/
https://www.ncbi.nlm.nih.gov/pubmed/29186197
http://dx.doi.org/10.1371/journal.pone.0188748

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