Cargando…

Fingolimod suppresses neuronal autophagy through the mTOR/p70S6K pathway and alleviates ischemic brain damage in mice

The bioactive, signaling lipid, sphingosine-1-phosphate (S1P), and its analog, fingolimod (FTY720), have previously shown neuroprotective effects against ischemic brain injury. However, the underlying mechanisms have not yet been fully clarified. The roles of autophagy in ischemic stroke are being i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xiao, Wang, Ming-Huan, Qin, Chuan, Fan, Wen-Hui, Tian, Dai-Shi, Liu, Jun-Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706683/ https://www.ncbi.nlm.nih.gov/pubmed/29186197 http://dx.doi.org/10.1371/journal.pone.0188748

Ejemplares similares

Suppression of sirtuin 1 alleviates airway inflammation through mTOR-mediated autophagy
por: Wu, Yuanyuan, et al.
Publicado: (2020)

Autophagy activated by tuberin/mTOR/p70S6K suppression is a protective mechanism against local anaesthetics neurotoxicity
por: Xiong, Jingwei, et al.
Publicado: (2016)

Combining use of Phillyrin and autophagy blocker alleviates laryngeal squamous cell carcinoma via AMPK/mTOR/p70S6K signaling
por: Wang, Da-hua, et al.
Publicado: (2019)

Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response
por: Wang, Wenjun, et al.
Publicado: (2021)

Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling
por: Tang, Yanghua, et al.
Publicado: (2021)

Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
por: Li, Liuran, et al.
Publicado: (2021)

Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells
por: Zhong, Wenying, et al.
Publicado: (2020)

Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway
por: Shui, Liyan, et al.
Publicado: (2020)

Effects of Akt/mTOR/p70S6K Signaling Pathway Regulation on Neuron Remodeling Caused by Translocation Repair
por: Yuan, Yusong, et al.
Publicado: (2020)

PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy
por: Fan, Shengnuo, et al.
Publicado: (2015)

Polydatin regulates proliferation, apoptosis and autophagy in multiple myeloma cells through mTOR/p70s6k pathway
por: Yang, Baojun, et al.
Publicado: (2017)

Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR–p70S6K pathway
por: Zuo, Shi Qi, et al.
Publicado: (2021)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

Rapamycin Reduced Ischemic Brain Damage in Diabetic Animals Is Associated with Suppressions of mTOR and ERK1/2 Signaling
por: Liu, Ping, et al.
Publicado: (2016)

Defects in GABA metabolism affect selective autophagy pathways and are alleviated by mTOR inhibition
por: Lakhani, Ronak, et al.
Publicado: (2014)

Schizandrin Protects against OGD/R-Induced Neuronal Injury by Suppressing Autophagy: Involvement of the AMPK/mTOR Pathway
por: Wang, Guangyun, et al.
Publicado: (2019)

Eugenol Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Autophagy via AMPK-mTOR-P70S6K Pathway
por: Sun, Xiaowei, et al.
Publicado: (2020)

Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline
por: Lin, Shao Jian, et al.
Publicado: (2015)

Ivabradine protects rats against myocardial infarction through reinforcing autophagy via inhibiting PI3K/AKT/mTOR/p70S6K pathway
por: Dai, Yingnan, et al.
Publicado: (2021)

Mingmu Xiaomeng Tablets Restore Autophagy and Alleviate Diabetic Retinopathy by Inhibiting PI3K/Akt/mTOR Signaling
por: Fang, Yuwei, et al.
Publicado: (2021)

Senkyunolide H Affects Cerebral Ischemic Injury through Regulation on Autophagy of Neuronal Cells via P13K/AKT/mTOR Signaling Pathway
por: Zhao, Bei, et al.
Publicado: (2022)

mTOR Pathways in Cancer and Autophagy
por: Paquette, Mathieu, et al.
Publicado: (2018)

Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways
por: Lu, Rui, et al.
Publicado: (2023)

Poricoic acid A induces apoptosis and autophagy in ovarian cancer via modulating the mTOR/p70s6k signaling axis
por: Ma, Rui, et al.
Publicado: (2021)

Dihydroartemisinin Induces Endothelial Cell Autophagy through Suppression of the Akt/mTOR Pathway
por: Liu, Jing, et al.
Publicado: (2019)

Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells
por: Song, Lihua, et al.
Publicado: (2017)

Knockdown of anion exchanger 2 suppressed the growth of ovarian cancer cells via mTOR/p70S6K1 signaling
por: Zhang, Li-Jun, et al.
Publicado: (2017)

Inhibition of Akt/mTOR/p70S6K Signaling Activity With Huangkui Capsule Alleviates the Early Glomerular Pathological Changes in Diabetic Nephropathy
por: Wu, Wei, et al.
Publicado: (2018)

IL-17A-Mediated Excessive Autophagy Aggravated Neuronal Ischemic Injuries via Src-PP2B-mTOR Pathway
por: Liu, Ting, et al.
Publicado: (2019)

cPKCγ‐mediated down‐regulation of UCHL1 alleviates ischaemic neuronal injuries by decreasing autophagy via ERK‐mTOR pathway
por: Zhang, Dan, et al.
Publicado: (2017)

Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS–AMPK–mTOR axis
por: Li, Ming-yong, et al.
Publicado: (2019)

Hydrogen sulfide alleviates uremic cardiomyopathy by regulating PI3K/PKB/mTOR-mediated overactive autophagy in 5/6 nephrectomy mice
por: Feng, Jianan, et al.
Publicado: (2022)

Retracted: Senkyunolide H Affects Cerebral Ischemic Injury through Regulation on Autophagy of Neuronal Cells Via P13K/AKT/mTOR Signaling Pathway
por: Markers, Disease
Publicado: (2023)

ABBV-744 induces autophagy in gastric cancer cells by regulating PI3K/AKT/mTOR/p70S6k and MAPK signaling pathways
por: Wang, Kun, et al.
Publicado: (2023)

PSMD7 downregulation induces apoptosis and suppresses tumorigenesis of esophageal squamous cell carcinoma via the mTOR/p70S6K pathway
por: Shi, Ke, et al.
Publicado: (2018)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
por: Zheng, Xiangjin, et al.
Publicado: (2021)

Qi Dan Li Xin pill improves chronic heart failure by regulating mTOR/p70S6k-mediated autophagy and inhibiting apoptosis
por: Shi, Binhao, et al.
Publicado: (2020)

LINC01278 Induces Autophagy to Inhibit Tumour Progression by Suppressing the mTOR Signalling Pathway
por: Liu, Bo, et al.
Publicado: (2023)

The PI3K/Akt/mTOR pathway is involved in CVB3-induced autophagy of HeLa cells
por: Chang, Huan, et al.
Publicado: (2017)

Acute, Delayed and Chronic Remote Ischemic Conditioning Is Associated with Downregulation of mTOR and Enhanced Autophagy Signaling
por: Rohailla, Sagar, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fkajjbtr28upkkmr13gmt7g7qe