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Assemblies of amyloid-β(30–36) hexamer and its G33V/L34T mutants by replica-exchange molecular dynamics simulation
The aggregation of amyloid-β peptides is associated with the pathogenesis of Alzheimer’s disease, in which the 30–36 fragments play an important part as a fiber-forming hydrophobic region. The fibrillar structure of Aβ(30–36) has been detected by means of X-ray diffraction, but its oligomeric struct...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706729/ https://www.ncbi.nlm.nih.gov/pubmed/29186195 http://dx.doi.org/10.1371/journal.pone.0188794 |