The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells

The long-lived latent HIV-1 reservoir is the major barrier for complete cure of Acquired Immune Deficiency Syndrome (AIDS). Here we report that a novel bromodomain and extraterminal domain (BET) inhibitor bromosporine which can broadly target BETs, is able to potently reactivate HIV-1 replication in...

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Detalles Bibliográficos
Autores principales: Pan, Hanyu, Lu, Panpan, Shen, Yinzhong, Wang, Yanan, Jiang, Zhengtao, Yang, Xinyi, Zhong, Yangcheng, Yang, He, Khan, Inam Ulla, Zhou, Muya, Li, Bokang, Zhang, Ziyu, Xu, Jianqing, Lu, Hongzhou, Zhu, Huanzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706859/
https://www.ncbi.nlm.nih.gov/pubmed/29212213
http://dx.doi.org/10.18632/oncotarget.21585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706859/
https://www.ncbi.nlm.nih.gov/pubmed/29212213
http://dx.doi.org/10.18632/oncotarget.21585

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