RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells

Poly(ADP-ribose) polymerase 1 (PARP1), a critical DNA repair protein, is frequently upregulated in breast tumors with a key role in breast cancer progression. Consequently, PARP inhibitors have emerged as promising therapeutics for breast cancers with DNA repair deficiencies. However, relatively lit...

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Detalles Bibliográficos
Autores principales: Zhang, Ye, Liao, Xiao-Hong, Xie, Hong-Yan, Shao, Zhi-Min, Li, Da-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706891/
https://www.ncbi.nlm.nih.gov/pubmed/29212245
http://dx.doi.org/10.18632/oncotarget.21784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706891/
https://www.ncbi.nlm.nih.gov/pubmed/29212245
http://dx.doi.org/10.18632/oncotarget.21784

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