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Phosphorylation regulates connexin43/ZO-1 binding and release, an important step in gap junction turnover

To investigate whether connexin phosphorylation regulates the known role of zonula occludens-1 protein (ZO-1) in gap junction (GJ) function, we generated and analyzed a series of phosphomimetic and phosphorylation-dead mutants by mutating known conserved regulatory serine (S) residues 255, 279/282,...

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Detalles Bibliográficos
Autores principales: Thévenin, Anastasia F., Margraf, Rachel A., Fisher, Charles G., Kells-Andrews, Rachael M., Falk, Matthias M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706988/
https://www.ncbi.nlm.nih.gov/pubmed/29021339
http://dx.doi.org/10.1091/mbc.E16-07-0496