A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin

Cellular proliferation is antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the noncanonical Wnt signaling pathway and antagonistically inhibits...

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Detalles Bibliográficos
Autores principales: Aznar, Nicolas, Sun, Nina, Dunkel, Ying, Ear, Jason, Buschman, Matthew D., Ghosh, Pradipta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706997/
https://www.ncbi.nlm.nih.gov/pubmed/29021338
http://dx.doi.org/10.1091/mbc.E17-06-0405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706997/
https://www.ncbi.nlm.nih.gov/pubmed/29021338
http://dx.doi.org/10.1091/mbc.E17-06-0405

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