Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition

Reduction in nucleotide pools through the inhibition of mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) has been demonstrated to effectively reduce cancer cell proliferation and tumour growth. The current study sought to investigate whether this antiproliferative effect could be enhanced b...

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Detalles Bibliográficos
Autores principales: Arnould, Stéphanie, Rodier, Geneviève, Matar, Gisèle, Vincent, Charles, Pirot, Nelly, Delorme, Yoann, Berthet, Charlène, Buscail, Yoan, Noël, Jean Yohan, Lachambre, Simon, Jarlier, Marta, Bernex, Florence, Delpech, Hélène, Vidalain, Pierre Olivier, Janin, Yves L., Theillet, Charles, Sardet, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707016/
https://www.ncbi.nlm.nih.gov/pubmed/29221122
http://dx.doi.org/10.18632/oncotarget.19199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707016/
https://www.ncbi.nlm.nih.gov/pubmed/29221122
http://dx.doi.org/10.18632/oncotarget.19199

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