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Farnesyl phenolic enantiomers as natural MTH1 inhibitors from Ganoderma sinense

Cancer cells are more addictive to MTH1 than normal cells because of their dysfunctional redox regulations. MTH1 plays an important role to maintain tumor cell survival, while it is not indispensable for the growth of normal cells. Farnesyl phenols having a coumaroyl substitution are rather uncommon...

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Detalles Bibliográficos
Autores principales: Gao, Ya, Zhu, Lihan, Guo, Jing, Yuan, Ting, Wang, Liqing, Li, Hua, Chen, Lixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707067/
https://www.ncbi.nlm.nih.gov/pubmed/29221173
http://dx.doi.org/10.18632/oncotarget.21430