Differential modulation of Bax/Bcl-2 ratio and onset of caspase-3/7 activation induced by derivatives of Justicidin B in human melanoma cells A375

Diphyllin and its derivatives are well known cytotoxic natural products structurally related to the anti-cancer drug podophyllotoxin. We here study their structure-activity relationship upon human melanoma cells for first time. To this end, human melanoma A375 cells were incubated with Justicidin B...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Qathama, Aljawharah, Gibbons, Simon, Prieto, Jose M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707076/
https://www.ncbi.nlm.nih.gov/pubmed/29221182
http://dx.doi.org/10.18632/oncotarget.21625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707076/
https://www.ncbi.nlm.nih.gov/pubmed/29221182
http://dx.doi.org/10.18632/oncotarget.21625

Ejemplares similares