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Differential modulation of Bax/Bcl-2 ratio and onset of caspase-3/7 activation induced by derivatives of Justicidin B in human melanoma cells A375

Diphyllin and its derivatives are well known cytotoxic natural products structurally related to the anti-cancer drug podophyllotoxin. We here study their structure-activity relationship upon human melanoma cells for first time. To this end, human melanoma A375 cells were incubated with Justicidin B...

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Detalles Bibliográficos
Autores principales:	Al-Qathama, Aljawharah, Gibbons, Simon, Prieto, Jose M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707076/ https://www.ncbi.nlm.nih.gov/pubmed/29221182 http://dx.doi.org/10.18632/oncotarget.21625

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