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Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine

The prelimbic prefrontal cortex is necessary for associating actions with their consequences, enabling goal-directed decision making. We find that the strength of action–outcome conditioning correlates with dendritic spine density in prelimbic cortex, suggesting that new action–outcome learning invo...

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Detalles Bibliográficos
Autores principales: Swanson, Andrew M., DePoy, Lauren M., Gourley, Shannon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707361/
https://www.ncbi.nlm.nih.gov/pubmed/29187752
http://dx.doi.org/10.1038/s41467-017-01915-4