Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading

The cytokines interleukin 1β and 6 (IL-1β, IL-6) mediate the acute phase response (APR). In liver, they regulate the secretion of acute phase proteins. Using RNA-seq in primary hepatocytes, we show that these cytokines regulate transcription in a bifurcated manner, leading to both synergistic and an...

Descripción completa

Detalles Bibliográficos
Autores principales: Goldstein, Ido, Paakinaho, Ville, Baek, Songjoon, Sung, Myong-Hee, Hager, Gordon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707366/
https://www.ncbi.nlm.nih.gov/pubmed/29185442
http://dx.doi.org/10.1038/s41467-017-02055-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707366/
https://www.ncbi.nlm.nih.gov/pubmed/29185442
http://dx.doi.org/10.1038/s41467-017-02055-5

Ejemplares similares