The Systemic Response to Topical Aldara Treatment is Mediated Through Direct TLR7 Stimulation as Imiquimod Enters the Circulation

Topical application of Aldara cream, containing the Toll-like receptor 7/8 agonist Imiquimod, is a widely used mouse model for investigating the pathogenesis of psoriasis. We have previously used this model to study the effects of peripheral inflammation on the brain, and reported a brain-specific r...

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Detalles Bibliográficos
Autores principales: Nerurkar, Louis, McColl, Alison, Graham, Gerard, Cavanagh, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707416/
https://www.ncbi.nlm.nih.gov/pubmed/29185473
http://dx.doi.org/10.1038/s41598-017-16707-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707416/
https://www.ncbi.nlm.nih.gov/pubmed/29185473
http://dx.doi.org/10.1038/s41598-017-16707-5

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