The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation

The assembly of proteins into amyloid fibrils, a phenomenon central to several currently incurable human diseases, is a process of high specificity that commonly tolerates only a low level of sequence mismatch in the component polypeptides. However, in many cases aggregation-prone polypeptides exist...

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Detalles Bibliográficos
Autores principales: Cukalevski, Risto, Yang, Xiaoting, Meisl, Georg, Weininger, Ulrich, Bernfur, Katja, Frohm, Birgitta, Knowles, Tuomas P. J., Linse, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707514/
https://www.ncbi.nlm.nih.gov/pubmed/29218188
http://dx.doi.org/10.1039/c4sc02517b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707514/
https://www.ncbi.nlm.nih.gov/pubmed/29218188
http://dx.doi.org/10.1039/c4sc02517b

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