Gene Editing in Human Lymphoid Cells: Role for Donor DNA, Type of Genomic Nuclease and Cell Selection Method

Programmable endonucleases introduce DNA breaks at specific sites, which are repaired by non-homologous end joining (NHEJ) or homology recombination (HDR). Genome editing in human lymphoid cells is challenging as these difficult-to-transfect cells may also inefficiently repair DNA by HDR. Here, we e...

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Detalles Bibliográficos
Autores principales: Zotova, Anastasia, Lopatukhina, Elena, Filatov, Alexander, Khaitov, Musa, Mazurov, Dmitriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707532/
https://www.ncbi.nlm.nih.gov/pubmed/29099045
http://dx.doi.org/10.3390/v9110325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707532/
https://www.ncbi.nlm.nih.gov/pubmed/29099045
http://dx.doi.org/10.3390/v9110325

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