Immunisation of two rodent species with new live-attenuated mutants of Yersinia pestis CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague

We showed recently that the live-attenuated Δlpp ΔmsbB Δail and Δlpp ΔmsbB::ailL2 mutants of Yersinia pestis CO92 provided short-term protection to mice against developing subsequent lethal pneumonic plague. These mutants were either deleted for genes encoding Braun lipoprotein (Lpp), an acetyltrans...

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Detalles Bibliográficos
Autores principales: Tiner, Bethany L, Sha, Jian, Cong, Yingzi, Kirtley, Michelle L, Andersson, Jourdan A, Chopra, Ashok K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707884/
https://www.ncbi.nlm.nih.gov/pubmed/29263858
http://dx.doi.org/10.1038/npjvaccines.2016.20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707884/
https://www.ncbi.nlm.nih.gov/pubmed/29263858
http://dx.doi.org/10.1038/npjvaccines.2016.20

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