PKM2 is not required for colon cancer initiated by APC loss

BACKGROUND: Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential in other tumor contexts, including a proposed non-metabolic...

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Detalles Bibliográficos
Autores principales: Lau, Allison N., Israelsen, William J., Roper, Jatin, Sinnamon, Mark J., Georgeon, Larissa, Dayton, Talya L., Hillis, Alissandra L., Yilmaz, Omer H., Di Vizio, Dolores, Hung, Kenneth E., Vander Heiden, Matthew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707917/
https://www.ncbi.nlm.nih.gov/pubmed/29214019
http://dx.doi.org/10.1186/s40170-017-0172-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707917/
https://www.ncbi.nlm.nih.gov/pubmed/29214019
http://dx.doi.org/10.1186/s40170-017-0172-1

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