Synthetic enhancer design by in silico compensatory evolution reveals flexibility and constraint in cis-regulation

BACKGROUND: Models that incorporate specific chemical mechanisms have been successful in describing the activity of Drosophila developmental enhancers as a function of underlying transcription factor binding motifs. Despite this, the minimum set of mechanisms required to reconstruct an enhancer from...

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Detalles Bibliográficos
Autores principales: Barr, Kenneth A., Martinez, Carlos, Moran, Jennifer R., Kim, Ah-Ram, Ramos, Alexandre F., Reinitz, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708098/
https://www.ncbi.nlm.nih.gov/pubmed/29187214
http://dx.doi.org/10.1186/s12918-017-0485-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708098/
https://www.ncbi.nlm.nih.gov/pubmed/29187214
http://dx.doi.org/10.1186/s12918-017-0485-2

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