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Synthetic enhancer design by in silico compensatory evolution reveals flexibility and constraint in cis-regulation
BACKGROUND: Models that incorporate specific chemical mechanisms have been successful in describing the activity of Drosophila developmental enhancers as a function of underlying transcription factor binding motifs. Despite this, the minimum set of mechanisms required to reconstruct an enhancer from...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708098/ https://www.ncbi.nlm.nih.gov/pubmed/29187214 http://dx.doi.org/10.1186/s12918-017-0485-2 |