Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA

Oligonucleotides containing internal triazole–3′-LNA linkages bind to complementary RNA with similar affinity and specificity to unmodified oligonucleotides, and significantly better than oligonucleotides containing triazole alone. In contrast LNA on the 5′-side of the triazole does not stabilise du...

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Detalles Bibliográficos
Autores principales: Kumar, Pawan, El-Sagheer, Afaf H., Truong, Lynda, Brown, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708354/
https://www.ncbi.nlm.nih.gov/pubmed/28748236
http://dx.doi.org/10.1039/c7cc05159j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708354/
https://www.ncbi.nlm.nih.gov/pubmed/28748236
http://dx.doi.org/10.1039/c7cc05159j

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