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Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA

Oligonucleotides containing internal triazole–3′-LNA linkages bind to complementary RNA with similar affinity and specificity to unmodified oligonucleotides, and significantly better than oligonucleotides containing triazole alone. In contrast LNA on the 5′-side of the triazole does not stabilise du...

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Detalles Bibliográficos
Autores principales:	Kumar, Pawan, El-Sagheer, Afaf H., Truong, Lynda, Brown, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708354/ https://www.ncbi.nlm.nih.gov/pubmed/28748236 http://dx.doi.org/10.1039/c7cc05159j

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